This study will develop an animal model of Alkaptonuria (AKU), a rare genetic disease for which there is no cure. The aim will be to investigate the effect of ochronosis, a blue-black discoloration of connective tissue which is the major cause of disability in AKU. The research will move towards therapies for AKU through an analysis of its natural course with a specific focus on ochronosis. We will record the effects of ochronosis in rodents, comparing the results to previous research.